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Istovremena primena leka Bensedin i opioida (lekova za ublažavanje jakih bolova, lekova za supstitucionu terapiji i određenih lekova protiv kašlja) povećava rizik od pospanosti, otežanog disanja (respiratorna depresija), kome što sve može biti životno ugrožavajuće. Zbog toga istovremenu primenu treba razmotriti samo ukoliko druge terapijs

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This drug may well lead to drowsiness, dizziness, or impair wondering or motor competencies; sufferers should steer clear of driving or functioning machinery right until adverse effects are established.Tramadol shouldn't be employed postoperatively in people approximately eighteen yrs right after tonsillectomy and/or adenoidectomy or in adolescents

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